Construct · 1 fields · 1 citations

stability-activity tradeoff: a standalone construct

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Biochemistry

the observation that residues needed for enzyme function often destabilize the fold, so mutations that raise stability tend to lower activity.

In biochemistry, stability-activity tradeoff refers to the observation that residues needed for enzyme function often destabilize the fold, so mutations that raise stability tend to lower activity. This meaning comes from Shoichet (1995) in Proceedings of the National Academy of Sciences.[1]

Unit
Recovery means
Measured by

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Nearby constructs

fold3 fields · 6 citationsjingle · one word, three constructs function5 fields · 6 citationsjingle · one word, five constructs observation2 fields · 2 citationsjingle · one word, two constructs

References

Shoichet, B. K., Baase, W. A., Kuroki, R., & Matthews, B. W. (1995). A relationship between protein stability and protein function. Proceedings of the National Academy of Sciences, 92(2), 452-456. https://doi.org/10.1073/pnas.92.2.452

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