Construct · 1 fields · 1 citations

swap: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaningderivativecompare the meanings
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swap1 CONSTRUCTDomain swapEISENBERG · PROTEIN SWAP

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Molecular biology

the exchange of a structural element, such as a helix or domain, between two identical protein chains.

Domain swapping is the exchange of a structural element, such as a helix, a loop, or a whole folded domain, between two identical protein chains, so that each chain completes its fold using a piece donated by its partner rather than by itself. Bennett, Choe, and Eisenberg's 1994 Domain swapping: entangling alliances between proteins described this mechanism and proposed it as a route to protein dimers and larger assemblies. The referent is a physical rearrangement of parts of protein molecules, observed by structural methods, and it has nothing to do with a contract that exchanges payments or an instruction that exchanges two values.[1]

Unit
One reciprocal exchange of a segment between two protein chains
Recovery means
Not applicable
Measured by
Detected by X-ray crystallography, comparison of monomer and dimer structures, and mutation of the connecting hinge region

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Nearby constructs

arbitrage3 fields · 3 citationsjingle · one word, three constructsallele3 fields · 5 citationsjingle · one word, three constructsaliasing4 fields · 4 citationsjingle · one word, four constructs

References

  1. Bennett, M. J., Choe, S., & Eisenberg, D. (1994). Domain swapping: Entangling alliances between proteins. Proceedings of the National Academy of Sciences, 91(8), 3127–3131. https://doi.org/10.1073/pnas.91.8.3127

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