Construct · 1 fields · 1 citations

thick filament mechanosensing: a standalone construct

One name. One construct. A landmark on the map.

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Muscle physiology

mechanism in which load on the thick filament switches myosin motors from an off state to on, so force recruits more motors.

In muscle physiology, thick filament mechanosensing refers to mechanism in which load on the thick filament switches myosin motors from an off state to on, so force recruits more motors. This meaning comes from Linari (2015) in Nature.[1]

Unit
Recovery means
Measured by

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Nearby constructs

filament2 fields · 3 citationsjingle · one word, two constructs force5 fields · 9 citationsjingle · one word, five constructs load6 fields · 7 citationsjingle · one word, six constructs

References

Linari, M., Brunello, E., Reconditi, M., Fusi, L., Caremani, M., Narayanan, T., Piazzesi, G., Lombardi, V., & Irving, M. (2015). Force generation by skeletal muscle is controlled by mechanosensing in myosin filaments. Nature, 528(7581), 276-279. https://doi.org/10.1038/nature15727

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