Construct · 1 fields · 1 citations

two-hit model of cyst formation: a standalone construct

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two-hit model ofcyst formation1 CONSTRUCTTwo-hit model of cystQIAN · NEPHROLOGY

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Nephrology

proposal that renal cysts in dominant polycystic kidney disease arise when a somatic mutation inactivates the remaining normal gene copy in a tubular cell.

In nephrology, two-hit model of cyst formation refers to proposal that renal cysts in dominant polycystic kidney disease arise when a somatic mutation inactivates the remaining normal gene copy in a tubular cell. This meaning comes from Qian (1996) in Cell.[1]

Unit
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Nearby constructs

cell2 fields · 3 citationsjingle · one word, two constructsdominant1 fields · 1 citationsanchor · a standalone constructmodel3 fields · 3 citationsjingle · one word, three constructs

References

  1. Qian, F., Watnick, T. J., Onuchic, L. F., & Germino, G. G. (1996). The Molecular Basis of Focal Cyst Formation in Human Autosomal Dominant Polycystic Kidney Disease Type I. Cell, 87(6), 979-987. https://doi.org/10.1016/s0092-8674(00)81793-6

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