Construct · 1 fields · 1 citations

two-hit model of leukemogenesis: a standalone construct

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two-hit model ofleukemogenesis1 CONSTRUCTTwo-hit model ofGILLILAND · HEMATOLOGY

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Hematology

the proposal that acute myeloid leukemia needs a proliferation-driving class I mutation together with a differentiation-blocking class II mutation.

In hematology, two-hit model of leukemogenesis refers to the proposal that acute myeloid leukemia needs a proliferation-driving class I mutation together with a differentiation-blocking class II mutation. This meaning comes from Gilliland (2002) in Blood.[1]

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Nearby constructs

acute1 fields · 1 citationsanchor · a standalone constructclass3 fields · 3 citationsjingle · one word, three constructsmodel3 fields · 3 citationsjingle · one word, three constructs

References

  1. Gilliland, D. G., & Griffin, J. D. (2002). The roles of FLT3 in hematopoiesis and leukemia. Blood, 100(5), 1532-1542. https://doi.org/10.1182/blood-2002-02-0492

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