Construct · 1 fields · 1 citations

accelerated blood clearance: a standalone construct

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Drug delivery

loss of the long circulation of PEGylated carriers on repeat dosing, as anti-PEG antibodies from the first dose speed their removal by the liver.

In drug delivery, accelerated blood clearance refers to loss of the long circulation of PEGylated carriers on repeat dosing, as anti-PEG antibodies from the first dose speed their removal by the liver. This meaning comes from Ishida (2008) in International Journal of Pharmaceutics.[1]

Unit
Recovery means
Measured by

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Nearby constructs

circulation4 fields · 4 citationsjingle · one word, four constructs clearance1 fields · 2 citationsanchor · a standalone construct delivery1 fields · 1 citationsanchor · a standalone construct

References

Ishida, T., & Kiwada, H. (2008). Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes. International Journal of Pharmaceutics, 354(1-2), 56-62. https://doi.org/10.1016/j.ijpharm.2007.11.005

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