Construct · 1 fields · 1 citations

activity-by-contact model: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaning·not indexed

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Gene regulation

a quantitative rule predicting an enhancer's effect on a gene from the enhancer's activity times its contact frequency.

In gene regulation, activity-by-contact model refers to a quantitative rule predicting an enhancer's effect on a gene from the enhancer's activity times its contact frequency. This meaning comes from Fulco (2019) in Nature Genetics.[1]

Unit
Recovery means
Measured by

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Nearby constructs

contact2 fields · 3 citationsjingle · one word, two constructs enhancer1 fields · 1 citationsanchor · a standalone construct frequency4 fields · 7 citationsjingle · one word, four constructs

References

Fulco, C. P., Nasser, J., Jones, T. R., Munson, G., Bergman, D. T., Subramanian, V., Grossman, S. R., Anyoha, R., Doughty, B. R., Patwardhan, T. A., Nguyen, T. H., Kane, M., Perez, E. M., Durand, N. C., Lareau, C. A., Stamenova, E. K., Aiden, E. L., Lander, E. S., & Engreitz, J. M. (2019). Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations. Nature Genetics, 51(12), 1664-1669. https://doi.org/10.1038/s41588-019-0538-0

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