Construct · 1 fields · 1 citations

activity cliff: a standalone construct

One name. One construct. A landmark on the map.

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Medicinal chemistry

pair of structurally similar compounds with a large difference in potency, which breaks the similarity assumption behind QSAR models.

In medicinal chemistry, activity cliff refers to pair of structurally similar compounds with a large difference in potency, which breaks the similarity assumption behind QSAR models. This meaning comes from Maggiora (2006) in Journal of Chemical Information and Modeling.[1]

Unit
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Nearby constructs

information4 fields · 5 citationsjingle · one word, four constructs potency2 fields · 2 citationsjingle · one word, two constructs similarity3 fields · 4 citationsjingle · one word, three constructs

References

Maggiora, G. M. (2006). On Outliers and Activity CliffsWhy QSAR Often Disappoints. Journal of Chemical Information and Modeling, 46(4), 1535-1535. https://doi.org/10.1021/ci060117s

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