Construct · 1 fields · 1 citations

adaptive immune resistance: a standalone construct

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Oncology

a tumor's induction of inhibitory ligands such as PD-L1 in response to inflammatory signals from attacking T cells, shielding itself from immune attack.

In oncology, adaptive immune resistance refers to a tumor's induction of inhibitory ligands such as PD-L1 in response to inflammatory signals from attacking T cells, shielding itself from immune attack. This meaning comes from Taube (2012) in Science Translational Medicine.[1]

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Nearby constructs

attack4 fields · 10 citationsjingle · one word, four constructs induction4 fields · 4 citationsjingle · one word, four constructs resistance4 fields · 7 citationsjingle · one word, four constructs

References

Taube, J. M., Anders, R. A., Young, G. D., Xu, H., Sharma, R., McMiller, T. L., Chen, S., Klein, A. P., Pardoll, D. M., Topalian, S. L., & Chen, L. (2012). Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape. Science Translational Medicine, 4(127). https://doi.org/10.1126/scitranslmed.3003689

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