Construct · 1 fields · 1 citations

burden test: a standalone construct

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Statistical genetics

a rare-variant association test that collapses variants in a gene into one score per person and tests that score against the trait.

In statistical genetics, burden test refers to a rare-variant association test that collapses variants in a gene into one score per person and tests that score against the trait. This meaning comes from Li (2008) in The American Journal of Human Genetics.[1]

Unit
Recovery means
Measured by

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Nearby constructs

association4 fields · 4 citationsjingle · one word, four constructs burden3 fields · 6 citationsjingle · one word, three constructs person3 fields · 6 citationsjingle · one word, three constructs

References

Li, B., & Leal, S. M. (2008). Methods for Detecting Associations with Rare Variants for Common Diseases: Application to Analysis of Sequence Data. The American Journal of Human Genetics, 83(3), 311-321. https://doi.org/10.1016/j.ajhg.2008.06.024

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