Construct · 1 fields · 1 citations

Extended Clearance Classification System: a standalone construct

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Pharmacokinetics

a scheme that sorts drugs by ionization, molecular weight and permeability to predict whether metabolism, renal excretion or hepatic uptake dominates their clearance.

In pharmacokinetics, Extended Clearance Classification System refers to a scheme that sorts drugs by ionization, molecular weight and permeability to predict whether metabolism, renal excretion or hepatic uptake dominates their clearance. This meaning comes from Varma (2015) in Pharmaceutical Research.[1]

Unit
Recovery means
Measured by

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Nearby constructs

clearance1 fields · 2 citationsanchor · a standalone construct metabolism3 fields · 3 citationsjingle · one word, three constructs permeability5 fields · 6 citationsjingle · one word, five constructs

References

Varma, M. V., Steyn, S. J., Allerton, C., & El-Kattan, A. F. (2015). Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS). Pharmaceutical Research, 32(12), 3785-3802. https://doi.org/10.1007/s11095-015-1749-4

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