Construct · 1 fields · 1 citations

first-pass: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaning·not indexed
first-pass1 CONSTRUCTFirst-pass metabolismPOND & TOZER · ELIMINATION

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Pharmacokinetics

metabolism of an oral drug in the gut wall and liver before it reaches the systemic circulation.

In pharmacokinetics, the first pass is the metabolism a drug undergoes, chiefly in the gut wall and liver, after oral absorption but before it reaches the systemic circulation, which can sharply reduce how much active drug becomes available. Pond and Tozer's 1984 review set out the basic concepts and clinical consequences of first-pass elimination. The referent is the fraction of an oral dose removed on its initial transit through eliminating organs, and it is unrelated to a compiler's opening scan beyond the shared image of a first traversal.[1]

Unit
The fraction of an oral dose eliminated before reaching systemic circulation
Recovery means
Not applicable
Measured by
Inferred from the drop in bioavailability relative to intravenous dosing, and from extraction ratios across gut and liver

Next

Run it through the Collider, or take the citations with you.

See how first-pass sits against neighbouring constructs in the Collider, or export every reference on this page in one click.

Open in ColliderExport BibTeXReport this entry

Nearby constructs

absorption6 fields · 6 citationsjingle · one word, six constructscirculation4 fields · 4 citationsjingle · one word, four constructscode3 fields · 6 citationsjingle · one word, three constructs

References

  1. Pond, S. M., & Tozer, T. N. (1984). First-pass elimination: Basic concepts and clinical consequences. Clinical Pharmacokinetics, 9(1), 1–25. https://doi.org/10.2165/00003088-198409010-00001

Cited on this page?

Confirm your construct, or correct us.

If your work is cited behind one of these entries, you know better than we do whether we captured the meaning right. Confirm it, suggest an edit, or dispute it, and your name goes on the entry as an author who has checked it, linked to your ORCID.

Claim your construct