Construct · 1 fields · 1 citations

homologous recombination deficiency score: a standalone construct

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homologous recombinationdeficiency score1 CONSTRUCTHomologous recombinationTELLI · PHARMACOGENOMICS

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Pharmacogenomics

a tumour genomic score combining loss of heterozygosity, telomeric allelic imbalance and large-scale state transitions to flag defective homologous recombination.

In pharmacogenomics, homologous recombination deficiency score refers to a tumour genomic score combining loss of heterozygosity, telomeric allelic imbalance and large-scale state transitions to flag defective homologous recombination. This meaning comes from Telli (2016) in Clinical Cancer Research.[1]

Unit
Recovery means
Measured by

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Nearby constructs

allele-specific expression1 fields · 1 citationsanchor · a standalone constructloss of heterozygosity1 fields · 1 citationsanchor · a standalone constructloss2 fields · 3 citationsjingle · one word, two constructs

References

  1. Telli, M. L., Timms, K. M., Reid, J., Hennessy, B., Mills, G. B., Jensen, K. C., Szallasi, Z., Barry, W. T., Winer, E. P., Tung, N. M., Isakoff, S. J., Ryan, P. D., Greene-Colozzi, A., Gutin, A., Sangale, Z., Iliev, D., Neff, C., Abkevich, V., Jones, J. T., Lanchbury, J. S., Hartman, A., Garber, J. E., Ford, J. M., Silver, D. P., & Richardson, A. L. (2016). Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer. Clinical Cancer Research, 22(15), 3764-3773. https://doi.org/10.1158/1078-0432.ccr-15-2477

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