Construct · 1 fields · 1 citations

loss of heterozygosity: a standalone construct

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Cancer biology

the loss of the normal allele at a locus where a person carries one mutant copy, unmasking a recessive tumor-suppressor defect.

In cancer biology, loss of heterozygosity refers to the loss of the normal allele at a locus where a person carries one mutant copy, unmasking a recessive tumor-suppressor defect. This meaning comes from Cavenee (1983) in Nature.[1]

Unit
Recovery means
Measured by

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Nearby constructs

allele3 fields · 5 citationsjingle · one word, three constructs defect4 fields · 7 citationsjingle · one word, four constructs homologous recombination deficiency score1 fields · 1 citationsanchor · a standalone construct

References

Cavenee, W. K., Dryja, T. P., Phillips, R. A., Benedict, W. F., Godbout, R., Gallie, B. L., Murphree, A. L., Strong, L. C., & White, R. L. (1983). Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature, 305(5937), 779-784. https://doi.org/10.1038/305779a0

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