Construct · 1 fields · 1 citations

molecular glue: a standalone construct

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Chemical biology

small molecule that induces or stabilizes an interaction between two proteins that would not otherwise bind, for example recruiting a target to a ligase.

In chemical biology, molecular glue refers to small molecule that induces or stabilizes an interaction between two proteins that would not otherwise bind, for example recruiting a target to a ligase. This meaning comes from Schreiber (2021) in Cell.[1]

Unit
Recovery means
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Nearby constructs

cell2 fields · 3 citationsjingle · one word, two constructs interaction3 fields · 7 citationsjingle · one word, three constructs target4 fields · 6 citationsjingle · one word, four constructs

References

Schreiber, S. L. (2021). The Rise of Molecular Glues. Cell, 184(1), 3-9. https://doi.org/10.1016/j.cell.2020.12.020

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