Construct · 1 fields · 1 citations

nadir: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaning·not indexed
nadir1 CONSTRUCTChemo nadirBODEY · NEUTROPENIA

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Oncology

The lowest blood count after chemotherapy

In oncology the nadir is the lowest point to which a blood-cell count (most importantly the neutrophil count) falls after a dose of myelosuppressive chemotherapy, before the marrow recovers. Bodey and colleagues' 1966 Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia established that infection risk rises steeply as the neutrophil count drops, which is why the timing and depth of the nadir govern clinical caution. The referent is the minimum of a recovering blood count over time, distinct from a point on the sky or the look-direction of a sensor.[1]

Unit
The minimum value a blood-cell count reaches after treatment, and the day it occurs
Recovery means
Counts recover from the nadir as the marrow repopulates, typically over days to a couple of weeks
Measured by
Found from serial blood counts as the lowest value, and its timing, after a dose

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Nearby constructs

acute1 fields · 1 citationsanchor · a standalone constructcount2 fields · 2 citationsjingle · one word, two constructsdepth3 fields · 6 citationsjingle · one word, three constructs

References

  1. Bodey, G. P., Buckley, M., Sathe, Y. S., & Freireich, E. J. (1966). Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia. Annals of Internal Medicine, 64(2), 328–340. https://doi.org/10.7326/0003-4819-64-2-328

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