Construct · 1 fields · 1 citations

off-target cleavage: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaning·not indexed

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Genome editing

cutting and mutation at genomic sites that only partly match the guide, the central specificity limit of nuclease editing.

In genome editing, off-target cleavage refers to cutting and mutation at genomic sites that only partly match the guide, the central specificity limit of nuclease editing. This meaning comes from Fu (2013) in Nature Biotechnology.[1]

Unit
Recovery means
Measured by

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Nearby constructs

cleavage3 fields · 3 citationsjingle · one word, three constructs editing1 fields · 2 citationsanchor · a standalone construct limit3 fields · 3 citationsjingle · one word, three constructs

References

Fu, Y., Foden, J. A., Khayter, C., Maeder, M. L., Reyon, D., Joung, J. K., & Sander, J. D. (2013). High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nature Biotechnology, 31(9), 822-826. https://doi.org/10.1038/nbt.2623

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