Construct · 1 fields · 1 citations

parallel tube model: a standalone construct

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paralleltube model1 CONSTRUCTParallel tube modelPANG · PHARMACOKINETICS

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Pharmacokinetics

hepatic clearance model in which drug concentration falls along parallel sinusoidal tubes from inflow to outflow, giving different predictions from the well-stirred model.

In pharmacokinetics, parallel tube model refers to hepatic clearance model in which drug concentration falls along parallel sinusoidal tubes from inflow to outflow, giving different predictions from the well-stirred model. This meaning comes from Pang (1977) in Journal of Pharmacokinetics and Biopharmaceutics.[1]

Unit
Recovery means
Measured by

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Nearby constructs

well-stirred model1 fields · 1 citationsanchor · a standalone constructclearance1 fields · 2 citationsanchor · a standalone constructconcentration4 fields · 4 citationsjingle · one word, four constructs

References

  1. Pang, K. S., & Rowland, M. (1977). Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance. Journal of Pharmacokinetics and Biopharmaceutics, 5(6), 625-653. https://doi.org/10.1007/bf01059688

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