Construct · 1 fields · 1 citations

well-stirred model: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaning·not indexed
well-stirredmodel1 CONSTRUCTWell-stirred modelPANG · PHARMACOKINETICS

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Pharmacokinetics

hepatic clearance model treating the liver as one well-mixed compartment whose drug concentration equals the outflowing blood.

In pharmacokinetics, well-stirred model refers to hepatic clearance model treating the liver as one well-mixed compartment whose drug concentration equals the outflowing blood. This meaning comes from Pang (1977) in Journal of Pharmacokinetics and Biopharmaceutics.[1]

Unit
Recovery means
Measured by

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Nearby constructs

parallel tube model1 fields · 1 citationsanchor · a standalone constructclearance1 fields · 2 citationsanchor · a standalone constructcompartment2 fields · 2 citationsjingle · one word, two constructs

References

  1. Pang, K. S., & Rowland, M. (1977). Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance. Journal of Pharmacokinetics and Biopharmaceutics, 5(6), 625-653. https://doi.org/10.1007/bf01059688

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