Construct · 1 fields · 1 citations
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A paratope is the antigen-binding site of an antibody, the small surface formed where the loops of the heavy- and light-chain variable domains come together and make contact with its target. It is the counterpart of the epitope, the patch on the antigen that it grips, and its shape and chemistry set which antigen the antibody recognises and how tightly. Perez and Zoete's 2025 Universal paratope–epitope interaction patterns in antibody–antigen structures analyses the recurring contact patterns such binding sites use. The referent is the antibody's own contact surface, distinct from the epitope it binds, and it is the structural seat of antibody specificity.[1]
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