Construct · 1 fields · 1 citations

partial agonist: a standalone construct

One name. One construct. A landmark on the map.

● anchor · submaximal receptor activation Nearest construct by meaning·not indexed
partialagonist1 CONSTRUCTPartial agonistSTEPHENSON · 1956

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Receptor pharmacology

A drug that binds fully but activates only partly

A partial agonist is a drug that occupies a receptor and produces a response, but a submaximal one, so that even at full occupancy it cannot elicit the maximal effect a full agonist can. Stephenson's 1956 modification of receptor theory separated a drug's affinity for the receptor from its efficacy in producing an effect, making room for agents that bind well yet drive only a fraction of the response. The referent is a drug defined by intermediate efficacy, which can also damp a full agonist's effect by competing for the same sites.[1]

Unit
The maximal response achievable relative to a full agonist at the same receptor
Recovery means
Not applicable
Measured by
Quantified by the ceiling of its dose-response relative to a full agonist (its intrinsic efficacy)

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Nearby constructs

receptor2 fields · 2 citationsjingle · one word, two constructsefficacy4 fields · 4 citationsjingle · one word, four constructsreceptor reserve1 fields · 2 citationsanchor · spare receptors, one field

References

  1. Stephenson, R. P. (1956). A modification of receptor theory. British Journal of Pharmacology and Chemotherapy, 11(4), 379–393. https://doi.org/10.1111/j.1476-5381.1956.tb00006.x

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