Construct · 1 fields · 2 citations

receptor reserve: a standalone construct

One name. One construct. A landmark on the map.

● anchor · spare receptors, one field Nearest construct by meaning·not indexed
receptorreserve1 CONSTRUCTReceptor reserveSTEPHENSON · SPARE

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Pharmacology

Full effect without binding every receptor

Receptor reserve, or the spare-receptor phenomenon, is the pharmacological finding that an agonist can produce its maximal tissue response while occupying only a fraction of the available receptors, leaving a reserve unbound. Stephenson's 1956 A modification of receptor theory separated a drug's efficacy from its occupancy to explain this, and Nickerson's 1956 Receptor occupancy and tissue response demonstrated a full response at low occupancy. The referent is the gap between the receptors actually needed for a maximal effect and the total present, a gap that raises a tissue's apparent sensitivity and shifts its dose-response curve leftward.[1][2]

Unit
The proportion of receptors not required to reach maximal response
Recovery means
Not applicable
Measured by
Revealed by irreversible receptor inactivation (e.g., with an alkylating antagonist), comparing dose-response shifts before and after

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Nearby constructs

occupancy2 fields · 3 citationsjingle · one word, two constructsefficacy4 fields · 4 citationsjingle · one word, four constructspartial agonist1 fields · 1 citationsanchor · submaximal receptor activation

References

  1. Stephenson, R. P. (1956). A modification of receptor theory. British Journal of Pharmacology and Chemotherapy, 11(4), 379–393. https://doi.org/10.1111/j.1476-5381.1956.tb00006.x
  2. Nickerson, M. (1956). Receptor occupancy and tissue response. Nature, 178(4535), 697–698. https://doi.org/10.1038/178697b0

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