Construct · 1 fields · 1 citations

prime editing: a standalone construct

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Molecular biology

a genome-editing method that writes new sequence into a target site using a reverse transcriptase and guide RNA, without double-strand breaks.

In molecular biology, prime editing refers to a genome-editing method that writes new sequence into a target site using a reverse transcriptase and guide RNA, without double-strand breaks. This meaning comes from Anzalone (2019) in Nature.[1]

Unit
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Nearby constructs

editing1 fields · 2 citationsanchor · a standalone construct prime2 fields · 4 citationsjingle · one word, two constructs sequence3 fields · 3 citationsjingle · one word, three constructs

References

Anzalone, A. V., Randolph, P. B., Davis, J. R., Sousa, A. A., Koblan, L. W., Levy, J. M., Chen, P. J., Wilson, C., Newby, G. A., Raguram, A., & Liu, D. R. (2019). Search-and-replace genome editing without double-strand breaks or donor DNA. Nature, 576(7785), 149-157. https://doi.org/10.1038/s41586-019-1711-4

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