Construct · 1 fields · 1 citations

protein urea denaturation curve analysis: a standalone construct

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protein urea denaturationcurve analysis1 CONSTRUCTProtein ureaPACE · BIOPHARMACEUTICAL

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Biopharmaceutical development

measuring conformational stability by unfolding with urea or guanidine and extrapolating the free energy back to water.

In biopharmaceutical development, protein urea denaturation curve analysis refers to measuring conformational stability by unfolding with urea or guanidine and extrapolating the free energy back to water. This meaning comes from Pace (1986) in Methods in Enzymology.[1]

Unit
Recovery means
Measured by

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Nearby constructs

linear extrapolation method1 fields · 1 citationsanchor · a standalone constructdenaturation2 fields · 2 citationsjingle · one word, two constructsdevelopment1 fields · 2 citationsanchor · a standalone construct

References

  1. Pace, C. N. (1986). [14]Determination and analysis of urea and guanidine hydrochloride denaturation curves. In Methods in Enzymology (pp. 266-280). Elsevier. https://doi.org/10.1016/0076-6879(86)31045-0

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