Construct · 1 fields · 1 citations

proteolysis targeting chimera: a standalone construct

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proteolysistargeting chimera1 CONSTRUCTProteolysis targetingSAKAMOTO · CHEMICAL BIOLOGY

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Chemical biology

bifunctional molecule that links a target-binding ligand to an E3 ubiquitin ligase ligand so the target is ubiquitinated and destroyed by the proteasome.

In chemical biology, proteolysis targeting chimera refers to bifunctional molecule that links a target-binding ligand to an E3 ubiquitin ligase ligand so the target is ubiquitinated and destroyed by the proteasome. This meaning comes from Sakamoto (2001) in Proceedings of the National Academy of Sciences.[1]

Unit
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Nearby constructs

chimera2 fields · 4 citationsjingle · one word, two constructsligand2 fields · 2 citationsinvariant · one construct, two systemstarget4 fields · 6 citationsjingle · one word, four constructs

References

  1. Sakamoto, K. M., Kim, K. B., Kumagai, A., Mercurio, F., Crews, C. M., & Deshaies, R. J. (2001). Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation. Proceedings of the National Academy of Sciences, 98(15), 8554-8559. https://doi.org/10.1073/pnas.141230798

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