Construct · 1 fields · 1 citations

rule of three: a standalone construct

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Medicinal chemistry

guideline that fragment library members should have molecular weight under 300, cLogP of 3 or less and at most three hydrogen-bond donors and acceptors.

In medicinal chemistry, rule of three refers to guideline that fragment library members should have molecular weight under 300, cLogP of 3 or less and at most three hydrogen-bond donors and acceptors. This meaning comes from Congreve (2003) in Drug Discovery Today.[1]

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library1 fields · 1 citationsanchor · a standalone construct weight4 fields · 4 citationsjingle · one word, four constructs

References

Congreve, M., Carr, R., Murray, C., & Jhoti, H. (2003). A ‘Rule of Three’ for fragment-based lead discovery? Drug Discovery Today, 8(19), 876-877. https://doi.org/10.1016/s1359-6446(03)02831-9

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