Construct · 1 fields · 1 citations

super-enhancer: a standalone construct

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Molecular biology

large clusters of enhancers densely bound by master transcription factors and Mediator that drive genes defining cell identity.

In molecular biology, super-enhancer refers to large clusters of enhancers densely bound by master transcription factors and Mediator that drive genes defining cell identity. This meaning comes from Whyte (2013) in Cell.[1]

Unit
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Nearby constructs

cell2 fields · 3 citationsjingle · one word, two constructs drive2 fields · 2 citationsjingle · one word, two constructs identity6 fields · 14 citationsjingle · one name, six constructs

References

Whyte, W. A., Orlando, D. A., Hnisz, D., Abraham, B. J., Lin, C. Y., Kagey, M. H., Rahl, P. B., Lee, T. I., & Young, R. A. (2013). Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes. Cell, 153(2), 307-319. https://doi.org/10.1016/j.cell.2013.03.035

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