Construct · 1 fields · 1 citations

synthetic lethality: a standalone construct

One name. One construct. A landmark on the map.

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Cancer biology

a genetic interaction in which loss of either of two genes is tolerated but loss of both kills the cell, exploited to target cancers.

In cancer biology, synthetic lethality refers to a genetic interaction in which loss of either of two genes is tolerated but loss of both kills the cell, exploited to target cancers. This meaning comes from Kaelin (2005) in Nature Reviews Cancer.[1]

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Nearby constructs

cell2 fields · 3 citationsjingle · one word, two constructs interaction3 fields · 7 citationsjingle · one word, three constructs loss2 fields · 3 citationsjingle · one word, two constructs

References

Kaelin, W. G. (2005). The Concept of Synthetic Lethality in the Context of Anticancer Therapy. Nature Reviews Cancer, 5(9), 689-698. https://doi.org/10.1038/nrc1691

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