Construct · 1 fields · 1 citations

target-mediated drug disposition: a standalone construct

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Pharmacokinetics

situation in which high-affinity binding to the pharmacological target is large enough to shape a drug's pharmacokinetics, often causing nonlinear disposition.

In pharmacokinetics, target-mediated drug disposition refers to situation in which high-affinity binding to the pharmacological target is large enough to shape a drug's pharmacokinetics, often causing nonlinear disposition. This meaning comes from Levy (1994) in Clinical Pharmacology & Therapeutics.[1]

Unit
Recovery means
Measured by

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Nearby constructs

binding4 fields · 4 citationsjingle · one word, four constructs disposition2 fields · 2 citationsjingle · one word, two constructs target4 fields · 6 citationsjingle · one word, four constructs

References

Levy, G. (1994). Pharmacologic target-mediated drug disposition. Clinical Pharmacology & Therapeutics, 56(3), 248-252. https://doi.org/10.1038/clpt.1994.134

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