Construct · 1 fields · 1 citations

ternary complex cooperativity: a standalone construct

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Chemical biology

degree to which a degrader's binding to one protein strengthens or weakens binding to the other, shaping the stability and selectivity of the ternary complex.

In chemical biology, ternary complex cooperativity refers to degree to which a degrader's binding to one protein strengthens or weakens binding to the other, shaping the stability and selectivity of the ternary complex. This meaning comes from Gadd (2017) in Nature Chemical Biology.[1]

Unit
Recovery means
Measured by

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Nearby constructs

binding4 fields · 4 citationsjingle · one word, four constructs complex4 fields · 4 citationsjingle · one word, four constructs cooperativity3 fields · 3 citationsinvariant · one construct, three systems

References

Gadd, M. S., Testa, A., Lucas, X., Chan, K., Chen, W., Lamont, D. J., Zengerle, M., & Ciulli, A. (2017). Structural basis of PROTAC cooperative recognition for selective protein degradation. Nature Chemical Biology, 13(5), 514-521. https://doi.org/10.1038/nchembio.2329

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