Construct · 1 fields · 1 citations

three pillars of survival: a standalone construct

One name. One construct. A landmark on the map.

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three pillarsof survival1 CONSTRUCTThree pillars ofMORGAN · DRUG DISCOVERY

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Drug discovery

principle that phase II success requires proof of exposure at the target site, target binding and expression of pharmacological activity.

In drug discovery, three pillars of survival refers to principle that phase II success requires proof of exposure at the target site, target binding and expression of pharmacological activity. This meaning comes from Morgan (2012) in Drug Discovery Today.[1]

Unit
Recovery means
Measured by

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Nearby constructs

binding4 fields · 4 citationsjingle · one word, four constructsexposure6 fields · 13 citationsjingle · one name, six constructsexpression4 fields · 4 citationsjingle · one word, four constructs

References

  1. Morgan, P., Van Der Graaf, P. H., Arrowsmith, J., Feltner, D. E., Drummond, K. S., Wegner, C. D., & Street, S. D. A. (2012). Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival. Drug Discovery Today, 17(9-10), 419-424. https://doi.org/10.1016/j.drudis.2011.12.020

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