Construct · 1 fields · 1 citations

two-signal model: a standalone construct

One name. One construct. A landmark on the map.

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two-signalmodel1 CONSTRUCTTwo-signal modelBRETSCHER · IMMUNOLOGY

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Immunology

the proposal that lymphocyte activation needs both antigen recognition and a second confirming signal, while antigen alone leads to tolerance.

In immunology, two-signal model refers to the proposal that lymphocyte activation needs both antigen recognition and a second confirming signal, while antigen alone leads to tolerance. This meaning comes from Bretscher (1970) in Science.[1]

Unit
Recovery means
Measured by

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Nearby constructs

two-signal model of lymphocyte activation1 fields · 1 citationsanchor · a standalone constructself-nonself discrimination1 fields · 1 citationsanchor · a standalone constructactivation4 fields · 4 citationsjingle · one word, four constructs

References

  1. Bretscher, P., & Cohn, M. (1970). A Theory of Self-Nonself Discrimination: Paralysis and induction involve the recognition of one and two determinants on an antigen, respectively. Science, 169(3950), 1042-1049. https://doi.org/10.1126/science.169.3950.1042

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