Construct · 1 fields · 1 citations

self-nonself discrimination: a standalone construct

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self-nonselfdiscrimination1 CONSTRUCTSelf-nonselfBRETSCHER · IMMUNOLOGY

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Immunology

the proposal that the immune system attacks foreign antigens while sparing the body's own, requiring help from a second signal to decide.

In immunology, self-nonself discrimination refers to the proposal that the immune system attacks foreign antigens while sparing the body's own, requiring help from a second signal to decide. This meaning comes from Bretscher (1970) in Science.[1]

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Nearby constructs

two-signal model of lymphocyte activation1 fields · 1 citationsanchor · a standalone constructtwo-signal model1 fields · 1 citationsanchor · a standalone constructbody2 fields · 3 citationsjingle · one word, two constructs

References

  1. Bretscher, P., & Cohn, M. (1970). A Theory of Self-Nonself Discrimination: Paralysis and induction involve the recognition of one and two determinants on an antigen, respectively. Science, 169(3950), 1042-1049. https://doi.org/10.1126/science.169.3950.1042

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