Construct · 2 fields · 4 citations
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In genetics, anticipation is the tendency of an inherited disorder to appear at an earlier age, and often with greater severity, in each successive generation of a family. Long dismissed as a reporting artifact, it was vindicated when Harley and colleagues' 1992 Unstable DNA sequence in myotonic dystrophy and Ashley and Warren's 1995 review traced it to unstable trinucleotide repeats that expand as they pass from parent to child, so a longer repeat brings earlier onset. The referent is a molecular-genetic pattern across generations, measured by age of onset against repeat length, nothing to do with a tone that arrives before its chord.[1][2]
In music an anticipation is a non-chord tone sounded before the harmony it belongs to arrives, so a voice reaches the next chord's note early and is then held or restruck when that chord sounds. Harmony texts such as Aldwell and Schachter's Harmony and voice leading and Kostka, Payne, and Almén's Tonal harmony group it among the embellishing tones, distinguished from a suspension or passing tone by its forward rather than lagging relation to the beat. The referent is a melodic-rhythmic ornament defined against an underlying chord, not an inherited disease pattern, sharing only the idea of something coming early.[3][4]
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