Construct · 1 fields · 1 citations

cellular thermal shift assay: a standalone construct

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cellular thermalshift assay1 CONSTRUCTCellular thermal shiftMOLINA · CHEMICAL BIOLOGY

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Chemical biology

method that measures drug binding to its target inside cells or tissues by detecting ligand-induced changes in the protein's thermal stability.

In chemical biology, cellular thermal shift assay refers to method that measures drug binding to its target inside cells or tissues by detecting ligand-induced changes in the protein's thermal stability. This meaning comes from Molina (2013) in Science.[1]

Unit
Recovery means
Measured by

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Nearby constructs

assay1 fields · 1 citationsanchor · a standalone constructbinding4 fields · 4 citationsjingle · one word, four constructsdifferential scanning fluorimetry melting temperature1 fields · 1 citationsanchor · a standalone construct

References

  1. Molina, D. M., Jafari, R., Ignatushchenko, M., Seki, T., Larsson, E. A., Dan, C., Sreekumar, L., Cao, Y., & Nordlund, P. (2013). Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay. Science, 341(6141), 84-87. https://doi.org/10.1126/science.1233606

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