Construct · 1 fields · 1 citations

extended ternary complex model: a standalone construct

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Pharmacology

revision of the ternary complex model allowing receptors to isomerize spontaneously into an active state that couples to G protein without agonist.

In pharmacology, extended ternary complex model refers to revision of the ternary complex model allowing receptors to isomerize spontaneously into an active state that couples to G protein without agonist. This meaning comes from Samama (1993) in Journal of Biological Chemistry.[1]

Unit
Recovery means
Measured by

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Nearby constructs

agonist1 fields · 3 citationsanchor · a standalone construct complex4 fields · 4 citationsjingle · one word, four constructs model3 fields · 3 citationsjingle · one word, three constructs

References

Samama, P., Cotecchia, S., Costa, T., & Lefkowitz, R. J. (1993). A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. Journal of Biological Chemistry, 268(7), 4625-4636. https://doi.org/10.1016/s0021-9258(18)53442-6

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