Construct · 1 fields · 1 citations

hitch: a standalone construct

One name. One construct. A landmark on the map.

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hitch1 CONSTRUCTHitch-hiking effectMAYNARD SMITH · 1974

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Population genetics

A neutral allele rides along with a selected one

In population genetics the hitch-hiking effect is the way a selectively neutral allele rises or falls in frequency not on its own merit but because it sits close on the chromosome to a gene under strong positive selection that is being swept toward fixation. Maynard Smith and Haigh's 1974 The hitch-hiking effect of a favourable gene showed that the sweep drags linked variants along and scours diversity around the selected site, a signature now used to detect selection in genomes. The referent is a change in allele frequency caused by linkage to a selected locus, a genetic free ride, sharing only the word with a sailor's knot.[1]

Unit
The frequency change of a neutral allele linked to a swept gene
Recovery means
Diversity around the swept site is gradually rebuilt by new mutation and recombination
Measured by
Detected from reduced heterozygosity and a skewed site-frequency spectrum flanking a selected locus

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Nearby constructs

bend1 fields · 1 citationsanchor · a standalone constructknot1 fields · 1 citationsanchor · a standalone constructallele3 fields · 5 citationsjingle · one word, three constructs

References

  1. Maynard Smith, J., & Haigh, J. (1974). The hitch-hiking effect of a favourable gene. Genetical Research, 23(1), 23–35. https://doi.org/10.1017/S0016672300014634

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