Construct · 1 fields · 1 citations

mechanistic static model: a standalone construct

One name. One construct. A landmark on the map.

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mechanisticstatic model1 CONSTRUCTMechanistic static modelFAHMI · PHARMACOKINETICS

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Pharmacokinetics

equation-based prediction of drug-drug interaction magnitude that combines reversible inhibition, inactivation and induction at fixed inhibitor concentrations.

In pharmacokinetics, mechanistic static model refers to equation-based prediction of drug-drug interaction magnitude that combines reversible inhibition, inactivation and induction at fixed inhibitor concentrations. This meaning comes from Fahmi (2009) in Drug Metabolism and Disposition.[1]

Unit
Recovery means
Measured by

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Nearby constructs

disposition2 fields · 2 citationsjingle · one word, two constructsinduction4 fields · 4 citationsjingle · one word, four constructsinhibition4 fields · 4 citationsjingle · one word, four suppressions

References

  1. Fahmi, O. A., Hurst, S., Plowchalk, D., Cook, J., Guo, F., Youdim, K., Dickins, M., Phipps, A., Darekar, A., Hyland, R., & Obach, R. S. (2009). Comparison of Different Algorithms for Predicting Clinical Drug-Drug Interactions, Based on the Use of CYP3A4 in Vitro Data: Predictions of Compounds as Precipitants of Interaction. Drug Metabolism and Disposition, 37(8), 1658-1666. https://doi.org/10.1124/dmd.108.026252

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