Construct · 1 fields · 1 citations

opsonization: a standalone construct

One name. One construct. A landmark on the map.

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opsonization1 CONSTRUCTOpsonizationWRIGHT & DOUGLAS · 1903

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Immunology

Coating a microbe so phagocytes can eat it

In immunology, opsonization is the coating of a microbe or particle with soluble molecules, such as specific antibody or complement fragments, that mark it for recognition and engulfment by phagocytes. Wright and Douglas's 1903 An experimental investigation of the rôle of the blood fluids in connection with phagocytosis showed that blood factors, which they named opsonins, must coat bacteria before phagocytes take them up efficiently. The referent is this tagging step that bridges a target to the receptors of an eating cell, greatly raising the rate of its clearance.[1]

Unit
The extent to which a target is coated with opsonins and the resulting rate of phagocytic uptake
Recovery means
Not applicable
Measured by
Measured by opsonophagocytic assays that record uptake or killing of opsonin-coated targets by phagocytes

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Nearby constructs

cell2 fields · 3 citationsjingle · one word, two constructsclearance1 fields · 2 citationsanchor · a standalone constructcomplement4 fields · 5 citationsjingle · one word, four constructs

References

  1. Wright, A. E., & Douglas, S. R. (1903). An experimental investigation of the rôle of the blood fluids in connection with phagocytosis. Proceedings of the Royal Society of London, 72, 357–370. https://doi.org/10.1098/rspl.1903.0062

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