Construct · 1 fields · 1 citations

reversible covalent inhibitor: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaning·not indexed
reversiblecovalent inhibitor1 CONSTRUCTReversible covalentSERAFIMOVA · MEDICINAL

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Medicinal chemistry

inhibitor whose tuned electrophile forms a covalent bond with a noncatalytic cysteine that can reverse, balancing potency with reduced permanent off-target modification.

In medicinal chemistry, reversible covalent inhibitor refers to inhibitor whose tuned electrophile forms a covalent bond with a noncatalytic cysteine that can reverse, balancing potency with reduced permanent off-target modification. This meaning comes from Serafimova (2012) in Nature Chemical Biology.[1]

Unit
Recovery means
Measured by

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Nearby constructs

bond2 fields · 2 citationsjingle · one word, two constructscovalent inhibitor1 fields · 1 citationsanchor · a standalone constructpotency2 fields · 2 citationsjingle · one word, two constructs

References

  1. Serafimova, I. M., Pufall, M. A., Krishnan, S., Duda, K., Cohen, M. S., Maglathlin, R. L., McFarland, J. M., Miller, R. M., Frödin, M., & Taunton, J. (2012). Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles. Nature Chemical Biology, 8(5), 471-476. https://doi.org/10.1038/nchembio.925

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