Construct · 1 fields · 1 citations

therapeutic index: a standalone construct

One name. One construct. A landmark on the map.

● anchor · the drug-safety-margin ratio Nearest construct by meaning·not indexed
therapeuticindex1 CONSTRUCTTherapeutic indexMULLER & MILTON · 2012

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Pharmacology

The gap between an effective dose and a toxic one

The therapeutic index is a measure of a drug's safety margin, classically the ratio of the dose or exposure that produces toxicity to the dose that produces the desired effect; a larger index means a wider gap between helping and harming. Muller and Milton's 2012 review sets out how the index is determined and interpreted across drug development, including its exposure-based refinements and limits. The referent is a comparative safety ratio that frames dosing decisions, not an effect in itself.[1]

Unit
The ratio of a toxic dose or exposure to an effective one
Recovery means
Not applicable
Measured by
Computed from dose- or exposure-response curves for efficacy and toxicity (e.g., TD50/ED50 or exposure margins)

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Nearby constructs

development1 fields · 2 citationsanchor · a standalone constructdose3 fields · 3 citationsinvariant · one construct, three systemsexposure6 fields · 13 citationsjingle · one name, six constructs

References

  1. Muller, P. Y., & Milton, M. N. (2012). The determination and interpretation of the therapeutic index in drug development. Nature Reviews Drug Discovery, 11(10), 751–761. https://doi.org/10.1038/nrd3801

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