Construct · 1 fields · 1 citations

time-dependent inhibition: a standalone construct

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Pharmacokinetics

enzyme inhibition that strengthens with time of exposure, including mechanism-based inactivation, posing a distinct drug-drug interaction risk.

In pharmacokinetics, time-dependent inhibition refers to enzyme inhibition that strengthens with time of exposure, including mechanism-based inactivation, posing a distinct drug-drug interaction risk. This meaning comes from Grimm (2009) in Drug Metabolism and Disposition.[1]

Unit
Recovery means
Measured by

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Nearby constructs

disposition2 fields · 2 citationsjingle · one word, two constructs exposure6 fields · 13 citationsjingle · one name, six constructs inhibition4 fields · 4 citationsjingle · one word, four suppressions

References

Grimm, S. W., Einolf, H. J., Hall, S. D., He, K., Lim, H., Ling, K. J., Lu, C., Nomeir, A. A., Seibert, E., Skordos, K. W., Tonn, G. R., Van Horn, R., Wang, R. W., Wong, Y. N., Yang, T. J., & Obach, R. S. (2009). The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America. Drug Metabolism and Disposition, 37(7), 1355-1370. https://doi.org/10.1124/dmd.109.026716

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