Construct · 1 fields · 1 citations

volume of distribution: a standalone construct

One name. One construct. A landmark on the map.

● anchor · apparent volume, one field Nearest construct by meaning·not indexed
volume ofdistribution1 CONSTRUCTVolume of distributionGIBALDI · APPARENT VOL

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Pharmacokinetics

the apparent volume a drug would occupy to account for its plasma concentration, the body amount divided by that concentration.

The volume of distribution is the apparent volume a drug would need to occupy to account for the plasma concentration seen after a known amount enters the body: the amount in the body divided by the plasma concentration. Gibaldi and Perrier's Pharmacokinetics treats it as a proportionality constant rather than a real anatomical space, so a drug that binds heavily to tissues can show a volume far larger than the body itself. The referent is a scaling factor linking dose to concentration that reflects how widely a drug partitions out of plasma into tissues, and together with clearance it sets the elimination half-life.[1]

Unit
An apparent volume (e.g., litres, or L/kg) relating body amount to plasma concentration
Recovery means
Not applicable
Measured by
Estimated as dose divided by the extrapolated initial plasma concentration, or from clearance and the elimination rate constant

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Nearby constructs

steady state3 fields · 3 citationsinvariant · one construct, three systemshalf-life3 fields · 3 citationsjingle · one word, three half-livesbody2 fields · 3 citationsjingle · one word, two constructs

References

  1. Gibaldi, M., & Perrier, D. (1982). Pharmacokinetics (2nd ed.). Marcel Dekker. ISBN 9780824710422

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