Construct · 1 fields · 1 citations

median effective dose: a standalone construct

One name. One construct. A landmark on the map.

● anchor · the dose for half, one field Nearest construct by meaning·not indexed
medianeffective dose1 CONSTRUCTMedian effective doseTREVAN · DOSE FOR HALF

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Pharmacology & toxicology

Dose that affects half the population

The median effective dose (ED50) is the dose that produces a defined all-or-none effect in half of a tested population; its toxic counterpart, the median lethal dose (LD50), is the dose lethal to half. Trevan's 1927 The error of determination of toxicity introduced this quantal, population-level measure because individual thresholds scatter, making a single 'effective dose' meaningless without reference to a proportion responding. The referent is a dose read off the cumulative distribution of individual sensitivities at the 50% point, the anchor for quantal dose-response analysis and for comparing drug potency and the therapeutic index.[1]

Unit
The dose at which 50% of a population shows the defined response
Recovery means
Not applicable
Measured by
Estimated from quantal dose-response curves (proportion responding vs. log dose), historically by probit analysis

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Nearby constructs

assay1 fields · 1 citationsanchor · a standalone constructdistribution2 fields · 2 citationsjingle · one word, two constructsdose3 fields · 3 citationsinvariant · one construct, three systems

References

  1. Trevan, J. W. (1927). The error of determination of toxicity. Proceedings of the Royal Society of London. Series B, 101(712), 483–514. https://doi.org/10.1098/rspb.1927.0030

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