Construct · 1 fields · 1 citations

orphan: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaning·not indexed
orphan1 CONSTRUCTOrphan drugHAFFNER · RARE DISEASE

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Pharmaceutical policy

A drug for a disease too rare to pay off

In drug development and policy, an orphan drug is a treatment for a disease so rare that, absent special incentives, no company would develop it because the market could never repay the cost; the condition is “orphaned” by ordinary economics. Haffner, Whitley, and Moses's 2002 review in Nature Reviews Drug Discovery recounts how the U.S. Orphan Drug Act of 1983 created incentives (exclusivity, tax credits) that turned a handful of such products into hundreds. The referent is a class of therapies defined by the rarity of their target disease, nothing to do with a parentless child, a stranded line of type, or a computing process, beyond the metaphor of being left without a sponsor.[1]

Unit
A therapy whose target disease falls below a defined prevalence threshold
Recovery means
Not applicable
Measured by
Identified by regulatory orphan designation tied to a disease-prevalence ceiling

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Nearby constructs

widow1 fields · 1 citationsanchor · a standalone constructattachment2 fields · 6 citationsjingle · one word, two constructsbeing3 fields · 3 citationsjingle · one word, three constructs

References

  1. Haffner, M. E., Whitley, J., & Moses, M. (2002). Two decades of orphan product development. Nature Reviews Drug Discovery, 1(10), 821–825. https://doi.org/10.1038/nrd919

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