Construct · 1 fields · 1 citations

prodrug: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a masked, bioactivated drug Nearest construct by meaning·not indexed
prodrug1 CONSTRUCTProdrugALBERT · 1958

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Pharmacology

An inactive compound the body converts to the active drug

A prodrug is a compound that is pharmacologically inactive, or much less active, as administered and is converted in the body, by enzymes or chemical conditions, into the active drug. Albert's 1958 discussion of selective toxicity introduced the idea of giving a substance that becomes effective only after metabolic change, a strategy used to improve absorption, targeting, or stability. The referent is a deliberately masked drug whose activity depends on in-vivo transformation.[1]

Unit
The extent and rate of conversion of the administered compound into its active form
Recovery means
Not applicable
Measured by
Characterized by the fraction converted to active drug and the kinetics of that bioconversion

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Nearby constructs

absorption6 fields · 6 citationsjingle · one word, six constructsbody2 fields · 3 citationsjingle · one word, two constructscompound3 fields · 3 citationsjingle · one word, three constructs

References

  1. Albert, A. (1958). Chemical aspects of selective toxicity. Nature, 182(4633), 421–423. https://doi.org/10.1038/182421a0

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